SYNTHESIS AND ANTICONVULSANT STUDIES OF 3-ANILINOPROPANAMIDES AND THEIR N-BENZYL DERIVATIVES
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
Abstract
The 3-ANPs (A01-A10) were prepared through acid catalysed Michael addition while the N-benzyl derivatives (A11-A15) were obtained through an uncatalysed amine exchange reaction with benzylamine. The structures of these compounds were established using various spectroscopic techniques. Compounds (A01-A15) were screened in mice against maximal electroshock (MES) and subcutaneous pentylene tetrazole (scPTZ) seizure models as well as the righting reflex test for neurological deficit. All the 15 compounds were active in the MES test with A04, A05, A07 and A13 being more potent than phenytoin. Compounds A05, A06 and A11-A15 were active in both MES and scPTZ seizures models and therefore have valproate-like activity. Compound A04 is the most potent (ED50 = 0.63mg/Kg) anti-MES compound ever reported in the literature while compound A13 is the most potent (MES ED50 = 3.25mg/Kg and scPTZ ED50 = 20.40mg/Kg) in the valproate class. The results of this work agrees with Unverferth et al (1998) and Shindikar et al (2006) proposed pharmacophores for anticonvulsants active at the voltage-dependent sodium channels. The compounds mentioned above are recommended for further studies.
Related Project Materials
A PHILOSOPHICAL LOOK INTO RELIGION AND FREEWILL IN THE LIGHT OF JAMES WILLIAM
STATEMENT OF PROBLEM
I have come to find out through history that almost all the wars and rancor that ravage the world...
AN ASSESSMENT OF THE PREVALENCE OF STUDENTS ABDUCTION IN NIGERIA AND POSSIBLE MITIGATING STRATEGIES(CASE STUDY OF LAGOS STATE)
BACKGROUND OF THE STUDY
Abduction is a process of forcefully taking someone and holding them hosta...
AN ANALYSIS OF THE LEGAL AND INSTITUTIONAL FRAMEWORK FOR THE REALIZATION OF THE RIGHT TO HEALTH IN NIGERIA
ABSTRACT
Health is an important element of an individual life and also to the individual’s country. A country cannot develop with i...
ELEMENTAL ANALYSIS ON PTEROCARPUS MILDBREADII (OHA)SEED
ABSTRACT
Elemental analysis is the qualitative detection and quantitative determination of chemical elements(atoms,ions)in a sample(Fritz...
PSYCHOLOGY OF GENIUS IN ARTHUR SCHOPENHAUER
SIGNIFICANCE OF THE STUDY
The gift of genius whether by nature or nurture remains the flower of civilization and develop...
THE INFLUENCE OF EDUCATIONAL REFORMS ON VOCATIONAL TRAINING
Abstract: This research explores the influence of educational reforms on vocational trainin...
LANGUAGE AND GENDER, ANALYSING THE DIFFERENCE LANGUAGE USE BETWEEN MALE AND FEMALE
INTRODUCTION
People have always known that gender and language use are connected. Women and men however, do not use...
ANTIBACTERIAL EFFECT OF NEEM TREE (Azadirachta indica) LEAF EXRACT ON Staphylococcus aureus
Abstact
The main focus of this study...
DATABASE EMISSION OF CARBON IV OXIDE (CO2) IN NIGERIA
ABSTRACT
There is a general believe today that the increased emission of green house gases especially carbo...
INFLUENCE OF CLASSROOM SIZE ON ACADEMIC PERFORMANCE OF SECONDARY SCHOOL STUDENTS IN NIGERIA
ABSTRACT
This research was performed to examine the influence of class room size on academic performance of secondary sc...
