SYNTHESIS AND ANTICONVULSANT STUDIES OF 3-ANILINOPROPANAMIDES AND THEIR N-BENZYL DERIVATIVES
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
Abstract
The 3-ANPs (A01-A10) were prepared through acid catalysed Michael addition while the N-benzyl derivatives (A11-A15) were obtained through an uncatalysed amine exchange reaction with benzylamine. The structures of these compounds were established using various spectroscopic techniques. Compounds (A01-A15) were screened in mice against maximal electroshock (MES) and subcutaneous pentylene tetrazole (scPTZ) seizure models as well as the righting reflex test for neurological deficit. All the 15 compounds were active in the MES test with A04, A05, A07 and A13 being more potent than phenytoin. Compounds A05, A06 and A11-A15 were active in both MES and scPTZ seizures models and therefore have valproate-like activity. Compound A04 is the most potent (ED50 = 0.63mg/Kg) anti-MES compound ever reported in the literature while compound A13 is the most potent (MES ED50 = 3.25mg/Kg and scPTZ ED50 = 20.40mg/Kg) in the valproate class. The results of this work agrees with Unverferth et al (1998) and Shindikar et al (2006) proposed pharmacophores for anticonvulsants active at the voltage-dependent sodium channels. The compounds mentioned above are recommended for further studies.
Related Project Materials
CAUSES AND EFFECTS OF POLITICAL VIOLENCE IN GOMBE METROPOLIS
Background of study
Political violence refers to all collective attacks within a political community against the political regime, its ac...
INFLUENCE OF STUDENTS' ATTITUDES TO THE LEARNING OF MATHEMATICS ON THEIR ACADEMIC ACHIEVEMENTS IN SENIOR SECONDARY SCHOOLS
EXCERPT FROM THE STUDY
Lawsha and Hussain (2011) conducted a study on the secondary students’ attitude towards mat...
INFORMATION AND COMMUNICATION SKILLS NEEDED BY BUSINESS STUDIES TEACHERS IN JUNIOR SECONDARY SCHOOLS IN ADAMAWA STATE
ABSTRACT
This study investigated the Information and Communication Technology skil...
THE ROLE OF FINANCIAL CONTROL IN THE PUBLIC SECTOR
ABSTRACT
The primary concern here is to identify to what extent good accounting system in the Public Sector can en...
DESIGN AND IMPLEMENTATION OF WEB BASED SOCIAL NETWORKING WEBSITE
ABSTRACT
This study was centered on social network website. It was observed that connecting socially helps improvement of department acti...
INVESTIGATION ON THE EFFECT OF INTEGRATED GROUP BASED MASTERY LEARNING MODEL ON SOCIAL STUDIES STUDENT ACHIEVEMENT
Background of the study
Recent socio-political and economic developments in the world and within nations have res...
ADMINISTRATION OF THE DEATH PENALTY IN THE CRIMINAL JUSTICE SYSTEM IN GOMBE STATE: AN APPRAISAL
ABSTRACT
The main aims and objectives of this study titled; “ ADMINISTRATION OF THE DEATH PENALTY IN THE CRIMINAL JUSTICE SYSTEM IN...
THE IMPACT OF FOREIGN DIRECT INVESTMENT ON ECONOMIC DEVELOPMENT IN NIGERIA
Abstract
This research paper looks at foreign direct investment and economic development in Nigeria (20...
THE IMPACT OF MONEY DEPOSIT BANKS ON THE ECONOMIC DEVELOPMENT OF NIGERIA
ABSTRACT
This study sets out to investigate the impact of deposit money banks on economic development in Nigeria. Using...
DESIGN AND IMPLEMENTATION OF ENCRYPTED DATA BASE SYSTEM
INTRODUCTION
In the past, security was simply a matter of locking the door or storing files in a locked filing cabinet o...
